Heterocyclic sulfoxide and sulfone inhibitors of fatty acid amide hydrolase

Bioorg Med Chem Lett. 2005 Jan 3;15(1):103-6. doi: 10.1016/j.bmcl.2004.10.025.

Abstract

A novel series of heterocyclic sulfoxides and sulfones was prepared and examined as potential inhibitors of fatty acid amide hydrolase (FAAH), the enzyme responsible for inactivation of neuromodulating fatty acid amides including anandamide and oleamide.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Amidohydrolases / antagonists & inhibitors*
  • Enzyme Inhibitors / chemistry
  • Enzyme Inhibitors / pharmacology*
  • Heterocyclic Compounds / chemistry*
  • Sulfones / chemistry*
  • Sulfoxides / chemistry*

Substances

  • Enzyme Inhibitors
  • Heterocyclic Compounds
  • Sulfones
  • Sulfoxides
  • Amidohydrolases
  • fatty-acid amide hydrolase